Effect of Mannitol on Renal Function During Open-Heart Surgery

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Effects of hypertonic mannitol on renal function in open heart surgery.

An extracorporeal bypass was performed in mongrel dogs for 2 hours with or without hypertonic mannitol infusions. In animals given mannitol, the plasma osmolality was elevated maximally to 344 +/- 7.1 mOsm/L and the urine volume was maintained well during bypass. A hypertonic mannitol solution was effective in maintaining the CPAH during and after bypass, but was not effective in minimizing the...

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ژورنال

عنوان ژورنال: Annals of Surgery

سال: 1965

ISSN: 0003-4932

DOI: 10.1097/00000658-196501000-00008